Attenuated Heart Rate Response in REM Sleep Behavior Disorder and Parkinson's Disease
Identifieur interne : 001201 ( Main/Exploration ); précédent : 001200; suivant : 001202Attenuated Heart Rate Response in REM Sleep Behavior Disorder and Parkinson's Disease
Auteurs : Gertrud Laura Sorensen [Danemark] ; Jacob Kempfner [Danemark] ; Marielle Zoetmulder [Danemark] ; Helge B. D. Sorensen [Danemark] ; Poul Jennum [Danemark]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group and the idiopathic rapid-eye-movement sleep behavior disorder group. The heart rate response to leg movement was significantly lower in both Parkinson's groups and in the idiopathic rapid-eye-movement sleep behavior disorder group compared with the control group. The heart rate response for the idiopathic rapid-eye-movement sleep behavior disorder group was intermediate with respect to the control and the parkinsonian groups. The attenuated heart rate response may be a manifestation of the autonomic deficits experienced in Parkinson's disease. The idiopathic rapid-eye-movement sleep behavior disorder patients not only exhibited impaired motor symptoms but also incipient autonomic dysfunction, as revealed by the attenuated heart rate response.
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Disease</title><author><name sortKey="Sorensen, Gertrud Laura" sort="Sorensen, Gertrud Laura" uniqKey="Sorensen G" first="Gertrud Laura" last="Sorensen">Gertrud Laura Sorensen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Electrical Engineering, Technical University of Denmark</s1><s2>Kongens Lyngby</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Kongens Lyngby</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Center for Sleep Medicine, Glostrup University Hospital</s1><s2>Glostrup</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Glostrup</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Center for Healthy Aging, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Electrical Engineering, Technical University of Denmark</s1><s2>Kongens Lyngby</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Kongens Lyngby</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Center for Sleep Medicine, Glostrup University Hospital</s1><s2>Glostrup</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Glostrup</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Center for Healthy Aging, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Center for Sleep Medicine, Glostrup University Hospital</s1><s2>Glostrup</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Glostrup</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Center for Healthy Aging, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Bispebjerg Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B. D." last="Sorensen">Helge B. D. Sorensen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Electrical Engineering, Technical University of Denmark</s1><s2>Kongens Lyngby</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Kongens Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Center for Sleep Medicine, Glostrup University Hospital</s1><s2>Glostrup</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Glostrup</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Center for Healthy Aging, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arousal</term><term>Behavior</term><term>Dysfunction</term><term>Heart rate</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Rapid eye movement sleep</term><term>Sleep disorder</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Rythme cardiaque</term><term>Sommeil paradoxal</term><term>Comportement</term><term>Eveil</term><term>Trouble fonctionnel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group and the idiopathic rapid-eye-movement sleep behavior disorder group. The heart rate response to leg movement was significantly lower in both Parkinson's groups and in the idiopathic rapid-eye-movement sleep behavior disorder group compared with the control group. The heart rate response for the idiopathic rapid-eye-movement sleep behavior disorder group was intermediate with respect to the control and the parkinsonian groups. The attenuated heart rate response may be a manifestation of the autonomic deficits experienced in Parkinson's disease. The idiopathic rapid-eye-movement sleep behavior disorder patients not only exhibited impaired motor symptoms but also incipient autonomic dysfunction, as revealed by the attenuated heart rate response.</div></front></TEI><affiliations><list><country><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><country name="Danemark"><noRegion><name sortKey="Sorensen, Gertrud Laura" sort="Sorensen, Gertrud Laura" uniqKey="Sorensen G" first="Gertrud Laura" last="Sorensen">Gertrud Laura Sorensen</name></noRegion><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name><name sortKey="Sorensen, Gertrud Laura" sort="Sorensen, Gertrud Laura" uniqKey="Sorensen G" first="Gertrud Laura" last="Sorensen">Gertrud Laura Sorensen</name><name sortKey="Sorensen, Gertrud Laura" sort="Sorensen, Gertrud Laura" uniqKey="Sorensen G" first="Gertrud Laura" last="Sorensen">Gertrud Laura Sorensen</name><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B. D." last="Sorensen">Helge B. D. Sorensen</name><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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